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They are highly toxic to the liver and are amongst the major identified risk factors for hepatocellular carcinoma 10–12

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Metal Cofactors Regulation of GLXI and Product Inhibition of GLXII According to phylogenetic analyses, AtGLXI.1 and AtGLXI.2 are classified as Ni 2+ -dependent isoforms with two GLXI domains, whereas AtGLXI.3 is a Zn 2+ -dependent one-domain isoform [195]